The IL-1R1 (Tyr496) Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated from Bioss Inc. is a Rabbit Polyclonal antibody to IL1R1. This antibody recognizes Human, Mouse, and Rat antigen. The IL-1R1 (Tyr496) Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Immunohistochemistry - frozen.
Description
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex